Seton Hall dealt Creighton's Matt Warren his first loss of the season as the Pirates plated five runs in the seventh to take an 8-2 win.
The loss dropped the Bluejays to 23-14-1 overall and 8-2 in BIG EAST conference play. Seton Hall, meanwhile, moved to 33-9 on the season and 7-3 on conference.
The Bluejays and Pirates will continue their three-game series on Saturday, May 3 at 6:30 pm as Creighton celebrates Military/1st Responders Family night at TD Ameritrade Park Omaha.
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