Doug McDermott had 27 points and 11 rebounds and Gregory Echenique scored 13 points to help Creighton hold on and defeat Cincinnati 67-63 Friday afternoon in the second round of the Midwest Regional in Philadelphia.
Ethan Wragge added 12 for the Bluejays, who won their NCAA Tournament opener for the second straight year.
McDermott, the two-time Missouri Valley Conference player of the year and 2012 All-American, made all 11 free throws to help the seventh-seeded Bluejays (28-7) move on to play Duke at 8:40 p.m. Sunday on TBS.
Sean Kilpatrick's driving layup after Cincinnati had the arrow on a jump ball cut it to 64-63 with :17 left. Austin Chatman sank two free throws for Creighton. Kilpatrick's attempt at a tying three rimmed out and the Bearcats were whistled for traveling after grabbing the rebound. Chatman then hit one of two from the line to clinch it.