Emergency crews responded to 48th and Cornhusker just before 6:00 p.m. Saturday.
Deputies say there were not witnesses, so they're still trying to figure out what happened.
It appeared one car had its front smashed in, and the other ended up down in the ditch.
Deputies tell us two victims were taken to Creighton, and another was taken to the Bellevue Medical Center.
The extent of their injuries is unknown at this time.