Two cars collided head-on just north of Crescent on Old Lincoln Highway around 9:30 p.m. Thursday.
A woman in her 80s was taken by helicopter to Creighton University Medical Center in Omaha. In the other vehicle, a man and woman in their 20s were also rushed to the hospital.
The Pottawatamie County Sheriff's Department is investigating, trying to figure out exactly how the crash happened.